Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 8 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%
Top Medical Research Studies
9
Macrophage EVs combat iron overload
We delved into the connection between iron overload and its effects on heart function after a heart attack, also known as myocardial infarction (MI). Our research focused on utilizing macrophage-derived extracellular vesicles (EVs) as a natural therapy to help with excessive iron levels in the heart.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
9
We explored the role of iron therapy in patients suffering from acute myocardial infarction (AMI), particularly those with iron deficiency. This interesting study analyzed data from the Medical Information Mart in Intensive Care-IV database, focusing on patients admitted to an intensive care unit between 2008 and 2019.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
Most Useful Reviews
9
Improved hemoglobin levels
7 people found this helpful
The rescue! Three years ago, I struggled with treating my anaemia; my haemoglobin was stuck at 80. After taking this specific iron supplement for two years, my haemoglobin is now consistently 140. I no longer experience the headaches I used to, nor am I freezing like before. This product is irreplaceable for me.
9
Essential for women's health
1 people found this helpful
I've been using this supplement to combat anaemia and boost ferritin levels. In Japan, I found the local iron supplements had poor absorption. This product has been essential for my health, particularly during menstruation and potential pregnancy. Since starting it, my dizziness and heart pains have vanished.
9
Eliminated heart issues
This iron dietary supplement was indispensable during my pregnancy. I took one capsule daily with vitamin C, which contributed to the disappearance of my long-standing arrhythmia and tachycardia. My hair loss ceased, and my overall well-being improved. No side effects were noted; I highly recommend it!
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
- All Researches
9
Macrophage EVs combat iron overload
We delved into the connection between iron overload and its effects on heart function after a heart attack, also known as myocardial infarction (MI). Our research focused on utilizing macrophage-derived extracellular vesicles (EVs) as a natural therapy to help with excessive iron levels in the heart.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
9
We explored the role of iron therapy in patients suffering from acute myocardial infarction (AMI), particularly those with iron deficiency. This interesting study analyzed data from the Medical Information Mart in Intensive Care-IV database, focusing on patients admitted to an intensive care unit between 2008 and 2019.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved hemoglobin levels
7 people found this helpful
The rescue! Three years ago, I struggled with treating my anaemia; my haemoglobin was stuck at 80. After taking this specific iron supplement for two years, my haemoglobin is now consistently 140. I no longer experience the headaches I used to, nor am I freezing like before. This product is irreplaceable for me.
9
Essential for women's health
1 people found this helpful
I've been using this supplement to combat anaemia and boost ferritin levels. In Japan, I found the local iron supplements had poor absorption. This product has been essential for my health, particularly during menstruation and potential pregnancy. Since starting it, my dizziness and heart pains have vanished.
9
Eliminated heart issues
This iron dietary supplement was indispensable during my pregnancy. I took one capsule daily with vitamin C, which contributed to the disappearance of my long-standing arrhythmia and tachycardia. My hair loss ceased, and my overall well-being improved. No side effects were noted; I highly recommend it!
9
Fantastic for anaemia
My brother has heart problems, so we opted for this supplement. It’s fantastic for blood health, especially for those who are anaemic. Unlike typical iron supplements that can cause constipation or heavy bleeding, this product didn't, and I will definitely purchase it again.
8
Rapid effect noted
3 people found this helpful
This product works brilliantly. I experienced tachycardia and hypotonic crises, with a ferritin level of 10. After taking the supplement alongside vitamin C, I noticed a good effect within a week. Now on my second course, I'm very satisfied.
Frequently Asked Questions
8
Rapid effect noted
3 people found this helpful
This product works brilliantly. I experienced tachycardia and hypotonic crises, with a ferritin level of 10. After taking the supplement alongside vitamin C, I noticed a good effect within a week. Now on my second course, I'm very satisfied.
7.5
Significant health improvement
I ordered this iron supplement for my father, who had developed anaemia with low haemoglobin. After taking it, his health improved significantly, and he experienced less shortness of breath. Unlike previous medications, it didn’t cause digestive discomfort, and his haemoglobin levels rose after three weeks.
9
Improved hemoglobin levels
7 people found this helpful
The rescue! Three years ago, I struggled with treating my anaemia; my haemoglobin was stuck at 80. After taking this specific iron supplement for two years, my haemoglobin is now consistently 140. I no longer experience the headaches I used to, nor am I freezing like before. This product is irreplaceable for me.
9
Essential for women's health
1 people found this helpful
I've been using this supplement to combat anaemia and boost ferritin levels. In Japan, I found the local iron supplements had poor absorption. This product has been essential for my health, particularly during menstruation and potential pregnancy. Since starting it, my dizziness and heart pains have vanished.
9
Eliminated heart issues
This iron dietary supplement was indispensable during my pregnancy. I took one capsule daily with vitamin C, which contributed to the disappearance of my long-standing arrhythmia and tachycardia. My hair loss ceased, and my overall well-being improved. No side effects were noted; I highly recommend it!
7.5
Increased ferritin levels
I was advised by my doctor to take two pills a day during menstruation. After two months of consistent use, my ferritin rose from 16 to 65, and I feel much lighter now. Pairing it with vitamin C has improved absorption, and I recommend this dietary supplement to everyone.
9
We explored the role of iron therapy in patients suffering from acute myocardial infarction (AMI), particularly those with iron deficiency. This interesting study analyzed data from the Medical Information Mart in Intensive Care-IV database, focusing on patients admitted to an intensive care unit between 2008 and 2019.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
9
Macrophage EVs combat iron overload
We delved into the connection between iron overload and its effects on heart function after a heart attack, also known as myocardial infarction (MI). Our research focused on utilizing macrophage-derived extracellular vesicles (EVs) as a natural therapy to help with excessive iron levels in the heart.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
References
- Guo D, Yang X, Yu R, Geng J, Zhang X, et al. Macrophage-derived extracellular vesicles represent a promising endogenous iron-chelating therapy for iron overload and cardiac injury in myocardial infarction. J Nanobiotechnology. 2024;22:527. 10.1186/s12951-024-02800-1
- Ding Y, Zhang Y, Gao X, Hua C, Liu L, et al. Association of Iron Therapy with Mortality in Patients with Acute Myocardial Infarction and Iron Deficiency. Cardiovasc Toxicol. 2024;24:1018. 10.1007/s12012-024-09905-x
